Array Comparative Genomic Hybridization (UCSF Dermatopathology)November 13, 2018
Early detection and accurate diagnosis of melanoma are thought to be key in lowering disease mortality. Melanoma is definitively diagnosed by the histopathologic examination; however, approximately 15% of skin lesions may have ambiguous results and discordance in diagnosis can occur among dermatopathologists. Researchers have observed that benign and malignant melanocytic lesions have different gene expression signatures and that melanomas accumulate genomic changes, including copy number variants. This report reviews 1 such test, the Array Comparative Genomic Hybridization (CGH) test offered by the University of California, San Francisco (UCSF) Dermatopathology Service.
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