Health Technology Brief

supporting sound, evidence-based decision making

HT Briefs are concise technology assessment reports that provide an overall evaluation of the potential clinical and economic impact of new technologies
that are in the early stages of dissemination or of existing technologies that are being used for new applications.

View a sampling of our HT Briefs.

Atezolizumab (Tecentriq) for Non-Small Cell Lung Cancer

March 5, 2018 Health Technology Brief

Health Problem: Lung cancer is the second most common form of cancer in men (after prostate cancer) and women (after breast cancer), accounting for approximately 14% of all new cancers. Non-small cell lung cancer (NSCLC) accounts for > 80% of all lung cancer cases, and it includes 2 major types: non-squamous, including adenocarcinoma, large-cell carcinoma, and other cell types; and squamous cell (epidermoid) carcinoma. Adenocarcinoma is the most common type of lung cancer seen in the United States and is also the most frequently occurring histology in nonsmokers. Technology Description: Atezolizumab is an immune checkpoint inhibitor recently developed for the treatment...

Rezum System (NxThera Inc.) for Benign Prostatic Hyperplasia

February 28, 2018 Health Technology Brief

Health Problem: Benign prostatic hyperplasia (BPH) is an enlargement or growth of the prostate that affects approximately 8 million men in the United States, including 30% of men older than 50 years of age and nearly 70% of men older than 70 years of age. The enlarged prostate restricts the urethra and applies pressure on the base of the bladder. This restriction of the urethra can result in urination difficulties. Technology Description: The Rezum System is a minimally invasive, transurethral treatment for BPH that utilizes convective radiofrequency water vapor energy to ablate the hyperplastic tissue. The Rezum System consists of a...

Autologous Serum Eye Drops for the Treatment of Dry Eye Disease

February 23, 2018 Health Technology Brief

Health Problem: Dry eye disease (DED) is a group of tear film disorders attributed to reduced tear production or excessive tear evaporation and associated with ocular discomfort, visual symptoms, and possible disease of the ocular surface. DED is estimated to be present in 25% of all adults seen in ophthalmology and optometry clinics and in approximately 5 million adults ≥ 50 years of age. The clinical presentation with DED may include burning, stinging, a scratchy sensation, discharge, dryness, pain, visual disability, and redness followed by excess tearing. Technology Description: Autologous Serum Eye Drops (ASED) solution is prepared from a blood sample...

Single-Anastomosis Duodenal Switch for Weight Loss

February 7, 2018 Health Technology Brief

Health Problem: More than one-third of the adults in the United States are obese. Obesity is associated with elevated morbidity and mortality and with increased risk for the following conditions: hypertension, dyslipidemia, type 2 diabetes mellitus, coronary heart disease, stroke, gall bladder disease, osteoarthritis, sleep apnea and breathing problems, certain cancers, and mental illness (e.g., depression, anxiety). High levels of obesity are very unlikely to resolve without intervention and lifestyle changes alone fail to confer adequate weight loss for many patients. Bariatric surgery is generally recognized as an effective and durable treatment for higher classes of obesity in patients for...

coflex Interlaminar Stabilization Device (Paradigm Spine LLC) for Treatment of Lumbar Spinal Stenosis

January 25, 2018 Health Technology Brief

Description of Technology: The coflex Interlaminar Stabilization device is a functionally dynamic, implantable, titanium interspinous process device (IPD) that is intended to limit lumbar spinal extension in order to maintain direct neurological decompression, unload the facet joints, and stabilize the motion segment at the treated vertebral level(s). The coflex is a U-shaped implant with 2 pairs of serrated wings extending from the upper and lower long arms of the U. The U portion is inserted horizontally between 2 adjacent spinous processes. The wings are crimped over bone to hold the implant in place. The device is implanted after decompression of...