Health Technology Brief

supporting sound, evidence-based decision making

HT Briefs are concise technology assessment reports that provide an overall evaluation of the potential clinical and economic impact of new technologies
that are in the early stages of dissemination or of existing technologies that are being used for new applications.

View a sampling of our HT Briefs.

Micra Transcatheter Pacing System (Medtronic Inc.) for Single-Chamber Pacemaker Indications

December 31, 2019 Health Technology Brief

Health Problem: Bradycardia due to atrioventricular (AV) dysfunction or sinus node dysfunction may result in hemodynamic consequences. A permanent cardiac pacemaker (PM) is the definitive treatment for symptomatic bradycardia that is not caused by underlying disorders or medication. More than 600,000 PMs are implanted annually worldwide, with > 250,000 implanted in the United States each year. However, overall, traditional transvenous pacing systems (TVPMs) have a 10% complication rate, including lead- and pocket-related events. The transvenous leads are the most common source of complications, removal, and revision surgery. Technology Description: The Micra Transcatheter Pacing System (TPS) is a single-chamber right ventricular pacing device. The...

Sinuva (Intersect ENT Inc.) Steroid-Releasing Sinus Implant for the Treatment of Nasal Polyps After Ethmoid Sinus Surgery

December 31, 2019 Health Technology Brief

Health Problem: Chronic rhinosinusitis (CRS), commonly known as chronic sinusitis, is a condition in which the paranasal sinuses are chronically inflamed, interfering with drainage and causing mucus buildup. Chronic inflammation in sinuses can lead to facial swelling, pain, tenderness, fever, fatigue, and difficulty breathing through the nose. Patients with CRS may require ethmoid sinus surgery (ESS) to help resolve symptoms. The goal of ESS is to open the affected sinus ostia to allow normal sinus drainage while preserving as much bone and mucosal lining as possible. However, ESS outcomes are limited by recurrent inflammation, adhesion formation, and polyp regrowth. A...

Cardiac Contractility Modulation in Heart Failure Patients Using the Optimizer Smart System (Impulse Dynamics)

December 31, 2019 Health Technology Brief

Health Problem: Heart failure (HF) is a chronic condition that develops over time due to circumstances that overwork and damage the heart. The primary causes include coronary heart disease, high blood pressure, and diabetes. HF is characterized by the inability of the heart to pump blood efficiently. HF is estimated to affect approximately 5.7 million people in the United States. Currently, there is no cure for HF. It can affect both children and adults, although it most commonly occurs in adults 65 years of age or older. Technology Description: The Optimizer Smart System delivers cardiac contractility modulation (CCM) signals to the right ventricular...

DeNovo NT Natural Tissue Graft (Zimmer Inc.) for Articular Cartilage Repair of the Knee or Ankle

December 23, 2019 Health Technology Brief

Health Problem: Articular cartilage is a resilient connective tissue that covers and lubricates joints at the interfaces of long bones to reduce friction during movement. Articular cartilage lesions have been reported in 4% to 6% of all knee arthroscopies (up to 36% in athletes). Chondral and osteochondral lesions of the ankle are commonly related to ankle sprain, affecting 1 in every 10,000 individuals in the United States daily, with up to 50% of ankle fractures and sprains resulting in some form of articular cartilage lesion of the talus. Osteoarthritis, a potential complication from untreated cartilage defects, is the most common...

Laparoscopic Radiofrequency Volumetric Thermal Ablation (Acessa System; Halt Medical Inc.) for Treatment of Uterine Fibroids

December 20, 2019 Health Technology Brief

Health Problem: Uterine fibroids (UF) are benign tumors of the myometrium, the smooth muscle layer of the uterus. Approximately 25% of fibroids are symptomatic. Fibroids are the most common indication for hysterectomy and may be associated with infertility and adverse pregnancy outcomes. Technology Description: The Acessa System is a minimally invasive, uterine-sparing, ultrasound-guided system for performing laparoscopic radiofrequency volumetric thermal ablation (RFVTA) of UF in the outpatient setting. Multiple fibroids may be treated through a single uterine puncture. In addition to radiofrequency energy for ablation, the generator also performs traditional electrocautery for control of bleeding. No suturing or uterine incisions are...