Technology Prognosis

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gammaCore Transcutaneous Vagus Nerve Stimulator

February 2, 2018

GammaCore is a noninvasive handheld prescription device intended to deliver transcutaneous vagus nerve stimulation for the acute treatment of pain associated with episodic cluster headache or migraine headache in adults.  The device consists of a portable stimulator with a battery, signal-generating electronics, and a digital control user interface that controls signal amplitude. Two stainless steel round discs function as skin contact surfaces. A conductive gel is applied on the stimulation surfaces of the device prior to placement on the neck. The device delivers a mild electrical signal that is transmitted to the cervical branch of the vagus nerve; this stimulation is thought to cause the release of inhibitory neurotransmitters and reduce the overexpression of the excitatory neurotransmitter glutamate, which has been implicated in a number of different disorders, including headache.