Comparative Effectiveness Reviews

Comparative Effectiveness Reviews are a comprehensive and systematic review and critical analysis of available evidence for TWO or MORE medical technologies in a given class for which there are several published clinical trials and a substantial body of evidence. This report details an entire technology class for which there are one or more technology.

Skin Substitutes for Venous Leg Ulcers in Adults

Focus of the Report: This report compares the effectiveness and safety of skin substitutes (cellular and acellular) as an addition to standard wound care (SWC) with SWC alone and compared with the adjunct use of alternative skin substitute products to treat chronic or nonhealing venous leg ulcers in adults.

Comparative Effectiveness of Cellular Skin Substitutes for Chronic Foot Ulcers in Adults with Diabetes Mellitus

Health Problem: Diabetes mellitus (DM) can damage blood vessels, compromising blood flow and oxygen circulation. Resulting tissue hypoxia may contribute to failure of even minor wounds to heal. Chronic foot ulcers in people with DM (DFU) may occur when foot injuries, such as cuts, blisters, or sores, develop, worsen, and do not heal. Reasons …

Stereotactic Radiosurgery for Trigeminal Neuralgia

Health Problem: Trigeminal neuralgia (TGN) is a neurological condition that can cause severe pain that cannot be controlled with medication in some patients. Women are twice as likely to be affected as men and the disease most often presents after age 40 years, with a typical age of onset between 60 to 70 years.

Hybrid Maze Procedure for Atrial Fibrillation

Health Problem: Atrial fibrillation (AF) is a supraventricular, accelerated heart rhythm characterized by uncoordinated atrial activation that leads to inefficient, irregular atrial contraction. According to 2010 data, approximately 2.7 to 6.1 million people in the United States have AF. In both men and women, AF is associated with a signific…