Comparative Effectiveness Reviews

Comparative Effectiveness Reviews are a comprehensive and systematic review and critical analysis of available evidence for TWO or MORE medical technologies in a given class for which there are several published clinical trials and a substantial body of evidence. This report details an entire technology class for which there are one or more technology.

Comparative Effectiveness of Cellular Skin Substitutes for Chronic Foot Ulcers in Adults with Diabetes Mellitus

Health Problem: Diabetes mellitus (DM) can damage blood vessels, compromising blood flow and oxygen circulation. Resulting tissue hypoxia may contribute to failure of even minor wounds to heal. Chronic foot ulcers in people with DM (DFU) may occur when foot injuries, such as cuts, blisters, or sores, develop, worsen, and do not heal. Reasons …

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Comparative Effectiveness Review of Peroral Endoscopic Myotomy for Treatment of Esophageal Achalasia

Health Problem: Esophageal achalasia (EA) is an uncommon motility disorder of unknown etiology that is characterized by increased lower esophageal sphincter (LES) pressure and esophageal aperistalsis. Treatment for EA includes both conservative treatment options, such as pharmaceutical therapies or botulinum toxin injection, and invasive opti…

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Hybrid Maze Procedure for Atrial Fibrillation

Health Problem: Atrial fibrillation (AF) is a supraventricular, accelerated heart rhythm characterized by uncoordinated atrial activation that leads to inefficient, irregular atrial contraction. According to 2010 data, approximately 2.7 to 6.1 million people in the United States have AF. In both men and women, AF is associated with a signific…

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