Comparative Effectiveness Reviews

Comparative Effectiveness Reviews are a comprehensive and systematic review and critical analysis of available evidence for TWO or MORE medical technologies in a given class for which there are several published clinical trials and a substantial body of evidence. This report details an entire technology class for which there are one or more technology.

Comparative Effectiveness Review of Transcatheter Aortic Valve Implantation (TAVI) and Surgical Aortic Valve Replacement (SAVR) for Aortic Stenosis in Lower Risk Patients

Health Problem: Aortic stenosis (AS) is the most common cause of aortic valve disease in older patients; approximately 7% of the population > 65 years of age is affected. The prevalence of AS is approximately 0.4% among adults aged ≥ 18 to 75 years in the United States. At younger ages, AS is most often related to bicuspid aortic valve but in older patients, AS is related t…

read more

Comparative Effectiveness Review of Mandibular Advancement Devices for Sleep Apnea: A Review of Reviews

Health Problem: Obstructive sleep apnea (OSA) is a chronic disorder that is characterized by repeated starting and stopping of breathing during sleep. Patients with OSA typically exhibit loud snoring followed by periods of silence and then snorting, choking, or gasping upon continuation of breathing. This often leads to fragmented sleep and daytime sleepiness. The estimated pr…

read more

Comparative Effectiveness Review of Recombinant Human Bone Morphogenetic Protein (rhBMP) for Use in Spinal Fusion

Health Problem: It is estimated that 1.5 million bone-grafting operations are performed annually in the United States. One major application of bone grafting is in lumbar and cervical spinal fusion. Spinal fusion is performed for a variety of reasons, including trauma, herniated intervertebral discs, and degenerative disease. Spinal fusion has traditionally been performed with…

read more

Comparative Effectiveness Review of Acupuncture for the Treatment of Episodic and Chronic Tension-Type Headache and Episodic Migraine: A Review of Reviews

Health Problem: Headache is a common neurological condition characterized by aching or pain that occurs in 1 or more areas of the head, face, mouth, or neck. Headaches may be primary or secondary. Familiar types of primary headaches include tension-type (TTH), migraine, and cluster. Twenty percent of women and 9.7% of men in the United States report having had a severe headach…

read more

Comparative Effectiveness Review of Transanal Hemorrhoidal Dearterialization Versus Alternative Hemorrhoidal Treatments

Health Problem: Hemorrhoids are enlarged and/or symptomatic venous cushions in the rectum and anus. They are composed of clusters of vascular tissue, smooth muscle, and connective tissue. Symptomatic hemorrhoids are thought to develop when their supporting tissues deteriorate, causing abnormal downward displacement of the anal cushions and venous dilation. They can cause pain,…

read more

Comparative Effectiveness Review of Bupivacaine Liposome Injectable Suspension for Relief of Postoperative Pain Following Total Knee Arthroplasty: A Review of Reviews

Health Problem: More than 70 million surgical procedures are performed annually in the United States. Fewer than half of patients who undergo surgery report adequate postoperative pain relief. Controlling postoperative pain increases patient mobility, permits earlier return to activities of daily living, and reduces the risk for postoperative complications. According to 2010 s…

read more

Comparative Effectiveness Review of Acupuncture for the Treatment of Knee Osteoarthritis: Review of Reviews

Health Problem: Osteoarthritis (OA) of the knee is a common, debilitating, painful condition with few treatment options. The cartilage between the bones degenerates, no longer providing a smooth, gliding surface for motion or adequate cushioning. Damaged articular cartilage does not tend to heal and may progressively worsen and cause focal lesions, eventually leading to OA. Be…

read more

Comparative Effectiveness Review of Acupuncture for the Treatment of Chronic Lower Back Pain: A Review of Reviews

Health Problem: Approximately 70% of people in developed countries experience lower back pain (LBP) during their lives, and it becomes chronic in an estimated 20% of individuals. An estimated 85% of chronic LBP is of ambiguous etiology, and therefore unamenable to correction of an underlying condition. Pharmacological and surgical management of chronic LBP may have unwanted si…

read more

Comparative Effectiveness Review of Acupuncture for the Treatment of Substance Use Disorders: A Review of Reviews

Health Problem: Substance addiction is characterized by compulsive drug seeking, along with tolerance, dependence, craving, and relapse. Addiction and abuse of drugs, alcohol, and nicotine cost more than $740 billion a year in the United States, rooted in lost productivity, elevated crime, and increased healthcare costs.

Technology Description: The tech…

read more