Exagamglogene autotemcel (Casgevy; Vertex Pharmaceuticals and CRISPR Therapeutics) is an autologous genome-edited hematopoietic stem cell-based gene therapy indicated for the treatment of patients aged 12 years and older with transfusion-dependent beta thalassemia.
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
Automated Low-Flow Ascites Pump (alfapump; Sequana Medical NV) for Refractory Ascites
The automated low-flow ascites pump (alfapump; Sequana Medical NV) is an implantable wireless battery-powered pump for treatment of recurrent or refractory ascites due to liver cirrhosis.
Edison System (HistoSonics) for Histotripsy of Renal Tumors
The Edison System (HistoSonics) is a nonthermal focused ultrasound system with real-time image guidance under investigation for the noninvasive mechanical destruction of stage I primary solid renal tumors via histotripsy.
Eplontersen (Wainua; Ionis Pharmaceuticals Inc./AstraZeneca) for Hereditary Transthyretin-mediated Amyloid Polyneuropathy
Eplontersen (Wainua; Ionis Pharmaceuticals Inc./AstraZeneca) is an injectable transthyretin-directed antisense oligonucleotide indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.
Filsuvez (Birch Triterpenes) Topical Gel (Chiesi Global Rare Diseases) for Epidermolysis Bullosa
Filsuvez (birch triterpenes) topical gel (formerly Oleogel-S10; Chiesi Global Rare Diseases) is indicated for the treatment of wounds associated with dystrophic and junctional epidermolysis bullosa in adult and pediatric patients 6 months of age and older.
Globe Pulsed Field Mapping and Ablation System (Kardium Inc.) for Atrial Fibrillation
The Globe Pulsed Field Mapping and Ablation System is an investigational pulsed-field ablation system for treatment of atrial fibrillation.
Varipulse Pulsed Field Ablation Catheter (Biosense Webster Inc.) for Atrial Fibrillation
Varipulse is an investigational pulsed-field ablation system in development for treatment of paroxysmal atrial fibrillation.
EyeBOX (Oculogica) as an Aid in Diagnosis of Concussion
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of the EyeBOX test (Oculogica) as an aid in the diagnosis of concussion, also known as mild traumatic brain injury (mild TBI).
PulseSelect Pulsed Field Ablation (PFA) System (Medtronic Inc.) for Atrial Fibrillation
The PulseSelect system (Medtronic Inc.) is a pulsed field ablation (PFA) system indicated for cardiac electrophysiological mapping (stimulation and recording) and for treatment of drug refractory, recurrent, symptomatic paroxysmal atrial fibrillation or persistent atrial fibrillation (episode duration less than 1 year).
Lovotibeglogene Autotemcel (Lyfgenia; Bluebird Bio) for Sickle Cell Disease
Lovotibeglogene autotemcel (Lyfgenia; Bluebird Bio Inc.) is an autologous hematopoietic stem cell-based gene therapy indicated for the treatment of patients 12 years of age or older with sickle cell disease and a history of vaso-occlusive events.