Relyvrio (sodium phenylbutyrate/taurursodiol, formerly AMX0035; Amylyx Pharmaceuticals Inc.) is an oral fixed-dose combination drug indicated for the treatment of amyotrophic lateral sclerosis (ALS) in adults. As of April 4, 2024, Relyvrio has been withdrawn from the market.
Publications
Hayes Publications are available through the Hayes Knowledge Center, a portal to world-class research and unbiased analyses on the clinical, financial, and risk impacts of emerging, controversial, and disruptive healthcare technologies.Every Hayes publication is developed by multidisciplinary teams of clinicians and scientists using rigorous methods grounded in internally recognized standards for systematic review and Health Technology Assessment. Learn more about these evidence resources and see sample titles below.
See below for some of our recent publications.
TriClip G4 System (Abbott Medical) Transcatheter Tricuspid Valve Repair for Tricuspid Regurgitation
The TriClip G4 System (Abbott Medical) is a transcatheter tricuspid valve repair system indicated for improving quality of life and functional status in patients with symptomatic severe tricuspid regurgitation despite optimal medical therapy, who are at intermediate or greater risk for surgery and in whom transcatheter edge-to-edge valve repair is clinically appropriate and i…
Eko Low Ejection Fraction Tool (ELEFT; Eko Health Inc.) for Artificial Intelligence (AI)-based Stethoscope Detection of Low Ejection Fraction
The Eko Low Ejection Fraction Tool (ELEFT; Eko Health Inc.) is an artificial intelligence (AI)-based algorithm that analyzes single-lead electrocardiogram (ECG) data collected via a compatible Eko digital stethoscope as an aid in the detection of low left ventricular ejection fraction in adult patients during a routine physical examination. It is not intended as a sole means …
Hybrid Lumbar Disc Arthroplasty with Fusion for Treatment of Multilevel Degenerative Disc Disease
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of hybrid lumbar disc arthroplasty with fusion to treat multilevel degenerative disc disease (DDD).
The Spanner Prostatic Stent (SRS Medical) for Treatment of Male Bladder Outlet Obstruction Following Transurethral Treatment of the Prostate
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of The Spanner Prostatic Stent (SRS Medical) for treatment of male bladder outlet obstruction (BOO) following transurethral treatment of the prostate.
Remestemcel-L (Mesoblast Ltd.) for Acute Graft-Versus-Host Disease
Remestemcel-L is an investigational allogeneic liquid cell suspension of ex-vivo cultured adult human mesenchymal stem cells derived from healthy donor bone marrow proposed for the treatment of pediatric patients with acute graft-versus-host-disease (aGVHD) refractory to standard first-line steroid therapy.
Sotatercept-csrk (Winrevair; Merck & Co. Inc.) for Pulmonary Arterial Hypertension
Sotatercept-csrk (Winrevair; Merck &Co. Inc.) is an activin signaling inhibitor indicated for the treatment of adults with World Health Organization (WHO) Group 1 pulmonary arterial hypertension to increase exercise capacity, improve WHO functional class, and reduce the risk of clinical worsening events.
The Spanner Prostatic Stent (SRS Medical) for Primary Treatment of Male Bladder Outlet Obstruction
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of The Spanner Prostatic Stent (SRS Medical) for primary treatment of male bladder outlet obstruction for urinary function, symptom relief, and quality of life improvement.
Afamitresgene Autoleucel (Adaptimmune Therapeutics) for Advanced Synovial Sarcoma
Afamitresgene autoleucel is an investigational autologous engineered T-cell therapy for the treatment of HLA-A*02 positive patients with advanced synovial sarcoma expressing the MAGE-A4 antigen.
Minimally Invasive Posterior Sacroiliac Joint Fusion Using a Bone Allograft for Management of Sacroiliac Joint Pain
This report addresses whether full-text clinical studies, systematic reviews, and clinical practice guidelines and position statements support the use of minimally invasive posterior sacroiliac joint (SIJ) fusion using engineered bone allografts placed within the SIJ for management of chronic SIJ pain.