Humacyl is an off-the-shelf bioengineered human acellular vessel proposed for use as a hemodialysis access graft in patients with end stage renal disease (ESRD). This technology uses a process to decellularize donated human vascular smooth muscle cells, while preserving extracellular matrix proteins. This results in a tubular scaffold that is acellular at the time of implanta…
PublicationsResearched and Curated by Clinical and Scientific Experts.
Every Hayes clinical evidence report is developed by experienced teams that have been trusted by healthcare decision makers since 1989. Here is a sampling of our content that is being used every day to inform defensible, evidence-based decisions by payers and providers.
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The bridge-enhanced anterior cruciate ligament (ACL) repair (BEAR) implant is a proprietary bio-engineered bridging scaffold made from bovine collagen. It is intended to facilitate healing of a complete ACL tear. It was developed as an alternative to the current standard reconstruction treatment for torn ACLs.
Focus of the Report: This report focuses on the efficacy and safety of the calcitonin gene-related peptide (CGRP) receptor antagonist ubrogepant (Ubrelvy) for acute treatment of migraines.
Technology Description: Ubrogepant is approved for the acute treatment of migraine. Ubrogepant is a C…
Focus of the Report: This report evaluates the use of axicabtagene ciloleucel (Yescarta) for the treatment of relapsed or refractory (r/r) large B-cell lymphoma (LBCL).
Technology Description: Axicabtagene ciloleucel therapy is a form of chimeric antigen receptor (CAR) T-lymphocyte (T-…
Noninvasive Computed Fractional Flow Reserve from Computed Tomography (FFRCT) for Diagnosis of Coronary Artery Disease
Focus of the Report: This report focuses on fractional flow reserve (FFR), determined noninvasively via computed tomography (FFRCT), to detect coronary artery blockages, identified by coronary computed tomography angiography (CCTA), that may be responsible for myocardial ischemia in patients with known or suspected coronary artery disease (CA…
This report evaluates the analytical validity, clinical validity, and clinical utility of the EndoPredict (Myriad Genetics Laboratories Inc.) test.
Percutaneous Mitral Valve Repair for Secondary (Functional) Mitral Valve Regurgitation in High-Risk Adults
Focus of the Report: This report focuses on the use of the MitraClip Mitral Valve Repair System (Abbott Vascular Inc.) for treatment of secondary (or functional) mitral valve regurgitation (MR).
Technology Description: The MitraClip Mitral Valve Repair System is a minimally invasive d…
Berotralstat is an oral plasma kallikrein inhibitor indicated for prophylaxis to prevent attacks of hereditary angioedema (HAE) in adults and pediatric patients 12 years and older.
A radiolabeled monoclonal antibody targeting tumor antigen B7-H3 in development for intraventricular radioimmunotherapy for treatment of neuroblastoma central nervous system/leptomeningeal metastases.
Anifrolumab is an investigational fully human monoclonal antibody that binds to subunit 1 of the type I interferon (IFN) receptor, blocking the activity of all type I IFNs. It is proposed for the treatment of adults with moderately to severely active systemic lupus erythematosus (SLE) who are receiving standard care.