Chloroquine (and its metabolite, hydroxychloroquine) is an oral 4-aminoquinoline antimalarial agent that has demonstrated antiviral effects on SARS-CoV and SARS-CoV-2 in vitro. It is being evaluated for the treatment of COVID-19.
Publications
Researched and Curated by Clinical and Scientific Experts.Every Hayes clinical evidence report is developed by experienced teams that have been trusted by healthcare decision makers since 1989. Here is a sampling of our content that is being used every day to inform defensible, evidence-based decisions by payers and providers.
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Remestemcel-L for Acute Graft-Versus-Host Disease
Remestemcel-L is an allogeneic liquid cell suspension of ex-vivo cultured adult human mesenchymal stem cells derived from healthy donor bone marrow proposed for the treatment of pediatric patients with acute graft-versus-host-disease (aGVHD) refractory to standard first-line steroid therapy.
Expandable Interbody Cages for Cervical Spinal Fusion
Focus of the Report: This Health Technology Assessment focuses on expandable interbody cages (EICs) for cervical fusion in patients with degenerative disc disease (DDD).
Technology Description: Interbody fusion procedures involve the removal of a pathologic disc and insertion of interbody cages and bone grafts, with the aim of stabilizing the spine by …
Antibacterial Envelopes for the Prevention of Cardiac Implantable Electronic Device (CIED) Infections
Focus of the Report: This report focuses on the efficacy and safety of TYRX antibacterial envelopes (Medtronic Inc.) for the prevention of infection following implantation of cardiac implantable electronic devices (CIEDs).
Technology Description: The TYRX antibacterial envelope is a su…
Remdesivir for COVID-19
Remdesivir is an investigational, intravenously administered antiviral agent proposed for treatment of COVID-19.
ColonSentry (Stage Zero Life Sciences)
The report evaluates the analytical validity, clinical validity, and clinical utility of the ColonSentry liquid biopsy test, a gene expression assay intended to estimate the current relative risk of having colorectal cancer (CRC) for patients eligible for CRC screening.
Minimally Invasive Procedures for Thyroidectomy
Focus of the Report: This report focuses on minimally invasive techniques for thyroidectomy.
Technology Description: For minimally invasive thyroid surgery, patients are placed under general anesthesia and the procedure is performed through small incisions in the neck, breast, armpits,…
Satralizumab for Neuromyelitis Optica Spectrum Disorder
Satralizumab is an investigational anti-IL-6 receptor monoclonal antibody under FDA review for the treatment of neuromyelitis optica spectrum disorder in adults and adolescents. It is administered by subcutaneous injection.
Botulinum Toxin for Treatment of Gastroparesis
Focus of the Report: Use of botulinum toxin (BTX) for treatment of gastroparesis.
Technology Description: BTX, a neurotoxin produced by the bacterium Clostridium botulinum, inhibits the release of the neurotransmitter acetylcholine at the neuromuscular junction and causes muscle paralysis. B…
Glu-Plasminogen (Proposed Name: Ryplazim) for Congenital Plasminogen Deficiency
Ryplazim is an investigational intravenous plasminogen replacement therapy for treatment of congenital plasminogen deficiency in children and adults. Ryplazim is recovered from healthy donor plasma; plasminogen is extracted using a proprietary process. Purified isolated plasminogen is administered by intravenous infusion.