This report evaluates the clinical utility for use of cell-free DNA (cfDNA) screening for sex chromosome aneuploidies (SCAs) in women with singleton or multiple gestation pregnancies. There has been a large uptake of cfDNA fetal screening for common trisomies in women at high risk for fetal aneuploidy, with the majority of fetal cfDNA studies published in high-risk populations. In addition, some professional societies and medical practices support cfDNA screening for common trisomies for all pregnant women, regardless of risk. As many laboratories are offering analysis for SCAs along with common trisomies, it is important to evaluate published evidence for fetal cfDNA screening for these conditions.

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