Genetic Test Evaluation

understanding how genetic tests impact patient management

SLCO1B1 Pharmacogenomic Genotyping for Statin Dosing or Selection

August 4, 2016

This report examines the clinical utility of genotyping for SLCO1B1 variants in pediatric or adult patients needing treatment with a statin to reduce low-density lipoprotein cholesterol. The evidence for the use of genetic testing is evaluated with respect to selecting statin type or dose in order to improve statin prescribing and patient adherence, and to avoid adverse events such as skeletal muscle pain.