Focus of the Report: This report addressed the use of microfragmented adipose tissue (MFAT) as a stand-alone treatment via intra-articular injection for the treatment of osteoarthritis (OA).

Technology Description: To prepare MFAT for use in the joint, fat is extracted from another location in the patient’s body and then processed to microfragment the adipose tissue, yielding mesenchymal stem cells, pericytes, and endothelial cells. The microfragmented lipoaspirate is then injected intra-articularly into the affected joint(s).

Controversy: MFAT is a new technology and evaluation of its efficacy and safety for the treatment of OA is warranted, especially since there are many other available treatments.

Key Questions:

  • Is MFAT as a stand-alone treatment effective for treating OA?

  • How does MFAT compare with alternative treatments for OA?

  • Is treatment with MFAT safe?

  • Have specific patient selection criteria for the MFAT been established?

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