Health Problem: Glaucoma is a disease of the optic nerve characterized by loss of retinal ganglion cells; remodeling of the lamina cribrosa; structural changes to the nerve; elevated intraocular pressure (IOP); and progressive, irreversible loss of vision leading to blindness. Open-angle glaucoma (OAG) is associated with partial blockage of the flow of aqueous humor.
Technology Description: Canaloplasty (CP) is a minimally invasive glaucoma surgery that utilizes a specially designed microcatheter to dilate aqueous humor collector channels to reduce IOP. The microcatheter alleviates obstructions in the Schlemm canal (SC) by pushing through them physically and by injecting high-molecular-weight viscoelastic to viscodilate the SC. Additionally, at the end of the procedure, a tensioning suture is placed to stent the canal open.
Controversy: Trabeculectomy (TE), the standard surgical option for treating OAG, is known to be a very efficacious method of reducing IOP. However, TE also relies on a bleb-creating procedure, which can be painful and often leads to secondary complications and vision issues. CP is a minimally invasive blebless procedure that experts suggest could greatly reduce postoperative complications and need for follow-up. However, it is not known if CP can achieve the same efficacy that TE consistently delivers.
Is CP effective in treating OAG?
How does CP compare with other treatments for OAG?
Is CP safe?
Have definitive patient selection criteria been identified for CP?
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