Focus of the Report: This report focuses on the use of fecal microbiota transplantation (FMT) to treat adults with ulcerative colitis (UC).

Technology Description: FMT is a procedure by which processed stool from healthy donors is infused into a patient’s gastrointestinal (GI) system for the purpose of treating a disease associated with impaired gut microbiota. Methods used for FMT are not standardized and routes of administration include endoscopically placed nasoduodenal tube, retention enema, and colonoscopy.

Controversy: Whereas FMT is an established treatment modality for patients with recurrent Clostridium difficile infection, any role that FMT might have in the treatment of patients with UC has not been well defined in clinical studies. Controversial issues related to FMT in UC include donor selection, stool processing, dosing, route of administration, and frequency.

Key Questions:

  • Is FMT effective in treating patients with UC?

  • How does FMT compare with other treatments for UC?

  • Is FMT safe in patients with UC?

  • Have definitive patient selection criteria been identified for FMT in patients with UC?

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