Noninvasive fractional flow reserve deduced from computed tomography (FFRCT) involves computer-assisted processing of coronary computed tomography angiography (CCTA) images to estimate changes in blood pressure inside coronary arteries that have partial blockages, with the goal of determining how severely the blockages impede blood flow to the heart. FFRCT has been proposed as a replacement for invasive fractional flow reserve (FFR), which is performed during invasive coronary angiography, to help cardiologists decide whether percutaneous coronary interventions (PCIs) such as angioplasty and stenting should be performed or if medical therapy is appropriate.

FFRCT may enable avoidance of complications that can occur during invasive measurement of FFR or during and after PCI. FFRCT may help determine whether a patient needs treatment, and if so, whether medical therapy is appropriate instead of PCI, which obviates the need for invasive procedures.    

  • How does FFRCT compare with invasive FFR performed during invasive coronary angiography, and with other tests such as CCTA?
  • Does FFRCT provide information that improves the care and outcomes, including coronary artery disease (CAD) morbidity and mortality, of patients who have CAD?
  • Is FFRCT safe?
  • Which patients might be suitable candidates for FFRCT?

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