Purpose of Technology
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are monoclonal antibodies that target and inactivate the PCSK9 protein in the liver. This drug is intended to reduce the amount of harmful low-density lipoprotein cholesterol (LDL-C) circulating in the bloodstream, thus lowering patient risk for cardiovascular disease (CVD).
Is evolocumab effective in lowering cholesterol and decreasing cardiovascular risk?
Is evolocumab safe?
What is the comparative effectiveness of evolocumab with ezetimibe?
Have definitive patient selection criteria been established for patients with hypercholesterolemia or hyperlipidemia treated with evolocumab?
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