Purpose of Technology

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are monoclonal antibodies that target and inactivate the PCSK9 protein in the liver. This drug is intended to reduce the amount of harmful low-density lipoprotein cholesterol (LDL-C) circulating in the bloodstream, thus lowering patient risk for cardiovascular disease (CVD).

Relevant Questions

  • Is evolocumab effective in lowering cholesterol and decreasing cardiovascular risk?

  • Is evolocumab safe?

  • What is the comparative effectiveness of evolocumab with ezetimibe?

  • Have definitive patient selection criteria been established for patients with hypercholesterolemia or hyperlipidemia treated with evolocumab?

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