The Melphalan Hepatic Delivery System (M-HDS; proposed U.S. name, Hepzato Kit) is a catheter-based drug delivery and chemofiltration kit for intra-arterial administration of melphalan chemotherapy directly to the liver followed by extracorporeal filtration of hepatic venous blood to reduce melphalan concentration before returning blood to systemic circulation. It is used to perform percutaneous hepatic perfusion to treat liver-dominant metastatic ocular melanoma in adult patients. It is marketed in Europe under the brand name CHEMOSAT.

If you have a Hayes login, click here to view the full report on the Knowledge Center.