Health Technology Assessments

Health Technology Assessments (HTAs) are a comprehensive systematic review and critical analysis of available evidence for A SINGLE medical technology for which there are several published clinical trials and a substantial body of evidence. This report details an entire technology class for which there are one or more indications or patient populations in use.


Our analysts evaluate clinical trial data, along with information regarding safety issues, coverage policies from the private and public sectors, regulatory approvals, consensus statements, and an overall projection of the potential clinical efficacy and economic impact of the technology. Reports are reviewed annually up to 5 years post publication to determine if there is new literature or evidence that would impact a change in rating and warrant an updated report.

Botulinum Toxin for Treatment of Gastroparesis

Focus of the Report: Use of botulinum toxin (BTX) for treatment of gastroparesis.

Technology Description: BTX, a neurotoxin produced by the bacterium Clostridium botulinum, inhibits the release of the neurotransmitter acetylcholine at the neuromuscular junction and causes muscle paralysis. B…

Micro-Ultrasound for Diagnosis of Prostate Cancer

Focus of the Report: In its application to prostate biopsy, micro-ultrasound (mUS), also known as high-resolution ultrasound (US), not only provides guidance for the biopsy needle but also allows identification of features that cannot be revealed by conventional US. Thus, mUS has the potential to identify cancerous lesions that might otherwis…

Botulinum Toxin for Treatment of Raynaud Phenomenon

Focus of the Report: For use of botulinum toxin (BTX) for Raynaud phenomenon (RP).

Technology Description: BTX has been investigated as a treatment for various chronic painful conditions because of its potential to reduce muscle tension and modulate pain receptor activity in the central nervous system. For the treatment of RP, there is currently no sta…

ProACT Adjustable Continence Therapy (Uromedica) for Treatment of Post-Surgical Urinary Incontinence in Men

Focus of the Report: Implantation of the ProACT device for the treatment of adult men with post-prostate surgery urinary incontinence (UI).

Technology Description: The ProACT system is a medical implantable device that consists of 2 sets of urethral balloons connected to titanium volume adjustment ports via tubing. During ProACT device implantation, a …