Health Technology Brief

supporting sound, evidence-based decision making

HT Briefs are concise technology assessment reports that provide an overall evaluation of the potential clinical and economic impact of new technologies
that are in the early stages of dissemination or of existing technologies that are being used for new applications.

View a sampling of our HT Briefs.

CardioMEMS Implantable Hemodynamic Monitor (Abbott) for Managing Patients with Heart Failure

January 3, 2019 Health Technology Brief

Health Problem: Heart failure (HF) is a chronic condition that develops over time due to circumstances that overwork and damage the heart. The primary causes include coronary heart disease, high blood pressure, and diabetes. HF is characterized by the inability of the heart to pump blood efficiently. HF is estimated to affect approximately 5.7 million people in the United States. Technology Description: The CardioMEMS Implantable Hemodynamic Monitor (CM-IHM) system includes an implantable pulmonary artery pressure (PAP) sensor, a transvenous catheter delivery system, a patient home-monitoring electronic system, and a secure Internet-accessible database that allows clinicians to access patient data. The CM-IHM...

iFuse Implant System (SI-Bone Inc.) for Sacroiliac Joint Fusion for Treatment of Sacroiliac Joint Dysfunction

December 20, 2018 Health Technology Brief

Health Problem: Low back pain is the most common cause of chronic pain, with an estimated worldwide prevalence in adults ranging from 4% to 25%. The sacroiliac joint (SIJ) has been implicated as the primary source of pain in up to 10% to 30% of patients with chronic low back pain, although no widely accepted reference standard exists for the diagnosis of pain originating from the SIJ. Technology Description: The iFuse implant system consists of sterile, rigid, titanium rods that have a triangular cross-section to minimize rotation and maximize surface area of the SIJ. These implants are coated with a porous...

Hemospray for Endoscopic Hemostasis for Treatment of Upper Gastrointestinal Bleeding in Adults

December 17, 2018 Health Technology Brief

Health Problem: Gastrointestinal (GI) bleeding is a serious, often life-threatening, condition. There are many potential sources of GI bleeding, including an underlying condition with ulcerative and nonulcerative lesions, malignancy, or as a result of medical interventions. Vascular malformations may underlie GI bleeding as well. Estimates of acute upper GI bleeding range from 15 to 570 per 100,000 people, with wide variability depending on bleeding etiology and age. Bleeding incidence increases dramatically with age. Mortality due to upper GI hemorrhage is roughly 2%. Technology Description: Hemospray is an inorganic mineral-based powder that is deployed near a bleeding site using pressurized carbon dioxide....

Eculizumab (Soliris) for Treatment of Refractory Generalized Myasthenia Gravis

December 11, 2018 Health Technology Brief

Health Problem: Myasthenia gravis (MG) is a rare autoimmune disorder that impacts the neuromuscular system, leading to muscle weakness, particularly affecting the nasopharyngeal, limb, and respiratory muscles. MG is a progressive disease caused by autoantibodies that interfere with the transmission of acetylcholine from nerve endings to muscle cells. It is estimated that 36,000 to 60,000 people in the United States have MG. The current estimates of the mortality rate range from 0.06 to 0.89 deaths per million person-years. Technology Description: Eculizumab is a recombinant humanized monoclonal antibody that is used for the treatment of generalized MG in adults who are anti-acetylcholine...

Magnetic Sphincter Augmentation (LINX Reflux Management System) for Treatment of Gastroesophageal Reflux Disease

December 6, 2018 Health Technology Brief

Health Problem: Gastroesophageal reflux disease (GERD) is a disorder in which the normal function of the lower esophageal sphincter at the junction of the distal esophagus and stomach fails, allowing gastric fluid to reflux into the esophagus. Estimates suggest the prevalence of GERD in the United States ranges from 18% to 28%, with up to 40% of patients with GERD exhibiting an inadequate response to first-line treatment with pharmacotherapy. Technology Description: Magnetic sphincter augmentation (MSA) with the LINX Reflux Management System includes an expandable, circumferential bracelet of magnetic beads that is implanted via laparoscope around the external distal esophagus at the...